Disinfectant Compounds: Safety Data Sheets Revealed
To minimise the risk of contamination through one of the most common transmission pathways, surface disinfectants are an important means to achieve pathogen control within laboratory and animal facilities. Disinfectants should provide an appropriate spectrum of antimicrobial activity but at the same time, effects on human health, environmental safety and animal behaviour must also be taken in consideration.
The selection of a disinfectant depends on the biosafety level of the animal laboratory and the animal pathogen of concern in the facility. Therefore, when selecting a disinfectant, the elimination of the most resistant pathogen becomes essential to reduce any risk of infectious diseases on research animals; failure in the elimination of these pathogens will result in the invalidation of research, depopulation of the animal housed in the facility, staff welfare and significant economic loss.
The choice of disinfectant products should be carefully carried out through rigours risk assessments especially in facilities with biosafety level lab 2, 3 & 4, which contain pathogen able to cause disease to humans. Decontamination strategies, routines, and quality control activities should be then practised rigorously to maximise the effects of the disinfectant. The aspect to consider in the selection of a disinfection product is the hazards associated with the use of it and the consequent potential risks related to its incorrect use and adverse effects on health. Exposure to these products can also result in occupation
al illness hence, being aware and familiar with the Safety Data Sheets (SDS) help to understand the effects of the use of disinfectants.
Through careful consideration of the health hazards associated with compounds present in disinfectants, the selection of the products should ensure minimal effects to human health, environmental concern, laboratory equipment and as last but not least, products should avoid any adverse effect on the animals health. Disinfectants may have a variety of uses within a facility and it is important to recognise that some disinfectants are not appropriate for use other than cleaning wall, benches,and floors. So, to minimise any negative effect resulting from the exposure of animals to disinfectants, it is important to use the intended product, to read the label and product information before use, and to use the product in the recommended concentration.
Most widely used surface cleaning products are mainly based on bleach. Bleach is highly offensive inodour and relatively hazardous due to its caustic effects. It can induce eye and skin irritation, burns, and respiratory issues due to inhalation of toxic gases released when mixed with ammonia based products. Bleach can also cause discolour of fabric and soft material, and it is highly corrosive to metals. Alternative disinfectants as effective as chlorine bleach can be available for use within animal facilities with same mechanism of action, broad spectrum activity and suitability.
How to Ensure Prolonged Efficacy
Improved efficacy can be granted with prolonged antimicrobial activity by using products containinga anjuvant technology platform, which can provide extend persistence on the applied surface. A reduce hazard classification and suitable for use on all surface without compromise to the spectrum of operation. In the following table, we have compared the SDS of Sychem CONTROL Technology™ Platform with two major disinfectant products to show the effects and the risk associated with the use of aggressive and highly corrosive disinfectants to human and animal welfare within animal facilities. The table helps to understand how the selection of an appropriate disinfectant for a laboratory animal facility is a complex, multifactorial decision requiring consideration to human safety, environmental safety, and behavioural effects on research animals as well as meeting the needs of any facility.See the Products